1 edition of Ion Channels found in the catalog.
Volume 3 continues the series" focus on presenting the latest advances in the study of ion channels by including articles on developmental regulation of potassium channels, genetic studies of ion channels in Drosophila, kinetic properties and regulation of GABAA receptor channels, and other subjects.
|Statement||edited by Toshio Narahashi|
|The Physical Object|
|Format||[electronic resource] /|
|Pagination||1 online resource (366 pages)|
|Number of Pages||366|
Jan 20, · Filling the gap created over the past five years, during which many new techniques have entered the market, this book is directed at both the new and the experienced ion channel researcher wishing to learn more about the considerations and methods for studying recombinant ion channels. Reviews “The book is an extremely useful guide for the study of ion channels. This volume is well written and describes in appropriate detail protocols to study diverse ion channel types in .
(source: Nielsen Book Data) Summary Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life. When disease strikes, malfunction of ion channels or their dependent processes is often involved, either as the cause or effect of the illness. Ion Channels Down Under, Volume 79 provides up-to-date information on ion channel pharmacology, their pharmacological modulators, and their role in a diverse range of poorly treated medical conditions. This new volume covers specific topics relating to Receptors and the Diversity in their Structure and Pharmacology, Acid-Sensing Ion Channel.
The improved understanding of ion channel structure, achieved through the use of molecular biology techniques, has opened the way for the development of new drugs targeted at specific types of ion channels. This book provides a comprehensive, single-volume overview of the effects of different drugs and toxins on ionic channels. B. Ion Channels in Neurotransmission. Action potentials result in an orderly, sequential opening and closing of voltage- and ligand-gated channels along the neuronal axon. In the link below, you can see the sequential cycling of voltage-gated channels that propagates a localized action potential (membrane depolarization) along an axon towards a synapse.
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Handbook of Ion Channels - CRC Press Book. The New Benchmark for Ion Channels book the Latest Developments of Ion Channels Ion channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli.
They can often interact with the cellular en. Apr 06, · Handbook of Ion Channels illustrates the fundamental importance of these membrane proteins to human health and disease.
Renowned researchers from around the world introduce the technical aspects of ion channel research, provide a modern guide to the properties of major ion channels, and present powerful methods for modeling ion channel diseases /5(3). Ion Channels of Excitable Membranes begins with the classical biophysical work of Hodgkin and Huxley, continues with the roles of channels in cellular signaling, then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of Cited by: Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore.
Their functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane, controlling the flow of ions across secretory and epithelial cells, and regulating cell volume.
Ion Channel Pharmacology (ICP) is a research and development enterprise involved in studying Ion Channels book that bring about their effects by modulating ion channel functions.
Most drugs, one way or another, modulate ion channels either by activating or blocking them. In summary, ion channels are the integral membrane proteins which are usually present as assemblies of many subunit proteins [16, 19].
In most voltage-gated ion channels, α subunit is the pore-forming subunit, while β and γ are the auxiliary johnsonout.com: Kaneez Fatima Shad, Saad Salman, Saifullah Afridi, Muniba Tariq, Sajid Asghar. Ion transport in and out of the cell across the surface membrane, or among different intracellular compartments are mediated by membrane proteins known as “ion channels,” pumps, and transporters.
This book focuses on the first group of proteins. Ion channels are considered to be gated pores whose opening and closing may be intrinsic or. Jul 01, · Ion channels underlie a broad range of the most basic biological processes, from excitation and signaling to secretion and absorption.
Like enzymes, they are diverse and ubiquitous macromolecular catalysts with high substrate specificity and subject to strong regulation/5.
In a set of four interrelated volumes, The Ion Channel FactsBook provides a comprehensive framework of facts about channel molecules central to electrical signaling phenomena in living cells. The fourth volume is devoted to Voltage-gated Channel Families, including those molecular complexes activated or modulated by calcium, potassium, and.
Overview: Ion channels are pore-forming proteins that allow the flow of ions across membranes, either plasma membranes or the membranes of intracellular organelles (Hille, ). Many ion channels (such as most Na, K Ca and some Cl channels) are gated by voltage but others (such as certain K and Cl channels, TRP channels, ryanodine receptors and IP 3 receptors) are relatively voltage.
Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases.
It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. The amino acid sequences of many different ion channel proteins have been determined, and in a few cases the X-ray crystal structure of the channel is known as well.
Based on their structure, the majority of ion channels can be classified into six or seven superfamilies. For potassium-selective channels, which are among the best-characterized ion channels, four homologous transmembrane.
Understanding the physical structure of ion channels is obviously the key to sorting out how they actually work. For instance, much insight into the detailed operation of ion channels has come from recent X-ray crystallographic studies of a bacterial K+ channel (Figure ).
This particular molecule was chosen for analysis because the large quantity of channel protein needed for Cited by: 2. It is worth noting that bacteria have several voltage-gated ion channels (4,41,42). This is an interesting observation in conjunction with the fact that different neural ion channels have their.
Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life. When disease strikes, malfunction of ion channels or their dependent is often involved, either as the cause or the effect of the illness.
Thus, billions of dollars have been, and still are being, invested in research to understand the physiological and pathophysiological. Feb 25, · The New Benchmark for Understanding the Latest Developments of Ion ChannelsIon channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli.
They can often interact with the cellular environment due to their location at the surface of ceCited by: In the past few years, the scientific community has witnessed rapid and significant progress in the study of ion channels. Technological advance ment in biophysics, molecular biology, and immunology has been greatly accelerated, making it possible to conduct experiments that were deemed very.
May 01, · I think most of us are aware that the human body uses both chemical and electrical signalling to control its inner functions, but until I read this book I had certainly never realised that extent to which a rather strange electrical process (strange because it involves the flow not of electrons as in ‘normal’ electricity, but of ions) is handled by ion channels/5.
Bertil Hille (born October 10, ) is a professor in the Department of Physiology and Biophysics at the University of johnsonout.com is particularly well known for. It is now clear that ion channels play essential roles in cell biology and physiology and that their dysfunction is the root cause of many human diseases.
In Ion Channels: Methods and Protocols, internationally recognized biomedical scientists describe recent technological breakthroughs and demonstrate their use in successful experimental designs.
Ion Channels Are Proteins That Span the Cell Membrane. Currents Through Single Ion Channels Can Be Recorded. Ion Channels in All Cells Share Several Characteristics. The Flux of Ions Through a Channel Is Passive. The Opening and Closing of a Channel Involve Conformational Changes. The Structure of Ion Channels Is Inferred from Biophysical.Ion channels play a vital role in basic physiological functions such as generation of electrical activity in nerves and muscle, control of cardiac excitability, intracellular signaling, hormone secretion, cell proliferation and many other biological processes.Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life.
When disease strikes, malfunction of ion channels or their dependent is often involved, either as the cause or the effect of the illness.